Integrated multi-omics investigations reveal the key role of
2 20 Abstract 21 Di-(2-ethylhexyl) phthalate (DEHP) is the most widely used plasticizer worldwide with an annual 22 global production of over eight million tons. Because of its improper disposal, endocrine-disrupting 23 DEHP often accumulates in estuarine sediments in industrialized countries at sub-millimolar levels,
Diethylhexylphthalate as an environmental contaminant--a review,Di(2-ethylhexyl)phthalate (DEHP) is a priority pollutant in several countries; annual production amounts to 3-4 million tonnes. Approximately 95% is used as a plasticizer in polyvinylchloride (PVC). DEHP is emitted to the environment during the production of plastics and plastic products, during their use and after disposal.
Phthalate - an overview | ScienceDirect Topics
Phthalates are a family of compounds that are used extensively in medical, automotive, and cosmetics production. There are six different types of phthalates; DEHP (di-ethylhexyl phthalate), BBP (benzyl-butyl phthalate,), and DINP (diisononyl phthalate) have potent antiandrogenic properties.
OVERVIEW OF DIALKYL - CPSC,Dimethyl phthalate (DMP) 194.2 1 6.0x10-3 1.5¡ª2.1 4.3 5.5 284 Diethyl phthalate (DEP) 222.2 2 1.6 x10-3 2.5 1 -- 298 Di-n-butyl phthalate (DBP) 278.3 4 7.3 x10-5 4.6 1x10-2-69 340 Butyl benzyl phthalate (BBP) 298.3 4, 6 6.0 x10-7 4.8 2.8x10-3
Analysis of ortho-phthalates and other plasticizers
phthalates including diisononyl phthalate (DINP), di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in commercial products intended for use by infants and children [1].
Some Chemicals Present in Industrial and Consumer ... - IARC,The compounds evaluated include the widely used plasticizer di(2-ethylhexyl) phthalate and the food contaminant 4-methylimidazole. In view of the limited agent-specific information available from epidemiological studies, the IARC Monographs Working Group relied mainly on carcinogenicity bioassays, and mechanistic and other relevant data to ...
Di 2-ethylhexylphtalate in the aquatic and terrestrial
Di(2-ethylhexyl) phthalate (DEHP), the most widely used plasticizers in the world, has been regarded as an endocrine disrupting chemical with serious adverse health outcomes. Accumulating evidence strongly suggests that the undesirable biological effects of DEHP are meditated by its metabolites rather than itself.
Di(2-ethylhexyl)phthalate (DEHP): human metabolism,Di(2-ethylhexyl)phthalate (DEHP) is a reproductive and developmental toxicant in animals and a suspected endocrine modulator in humans. There is widespread exposure to DEHP in the general population. Patients can be additionally exposed through DEHP-containing medical devices. Toxicokinetic and meta ¡
Di(2-ethylhexyl) Phthalate Property Information
mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), for which the geometric mean level in the general population was 9.57 ¦Ìg/L (CDC 2018). The mean level in children aged 6 to 11 (18.2 ¦Ìg/L) was almost twice the population mean, exceeding the levels in both adolescents (aged 12 to 19) and adults (20 or older). Higher levels of a contami-
Plasticiser loss from plastic or rubber products through,The NBR sample initially contains 11 wt.% Di(2-ethylhexyl) phthalate ... S.-Y. Unentangled Star-Shape poly (¦Å-caprolactone) s as phthalate-free PVC plasticizers designed for non-toxicity and ...
Simultaneous and sensitive determination of the main metabolites of the plasticizer DEHP and its substitutes DEHTP, DINCH and ... - RSC Publishing
With the prominent but toxicologically critical plasticizer di-(2-ethylhexyl) phthalate (DEHP) declining, alternative plasticizers are increasingly used leading to a continuously more diverse exposure situation of humans with multiple plasticizers. Therefore, an on-line SPE-LC-MS/MS method for the simultaneo
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Temperature- and solvent-dependent migrations of di(2-ethylhexyl)phthalate, the hazardous plasticizer from commercial PVC blood storage bag
Di(2-ethylhexyl)phthalate (DEHP) is the predominant phthalic acid ester (PAE) mainly used to plasticize polyvinyl chloride (PVC) thermoplastics [1¨C3]. Since DEHP is bound only physically on to the PVC polymer or embedded in the mesh spaces of its net, it can easily be leached into the surrounding medium, and after cycling through the ecosystem it ultimately reaches in to humans [ 4 , 5 ].
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Alternative Plasticizers As Emerging Global Environmental and Health Threat: Another Regrettable Substitution? | Environmental Science & Technology
(1) Phthalate plasticizers have been regarded as hazardous compounds due to numerous reports based on its toxicological effects, including bioaccumulation potential, endocrine disruption, carcinogenicity, and developmental defects. (1?4) These findings resulted in global regulation measures and control of typical phthalate plasticizers (5?7) and...
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DEHP plasticizer and blood bags: challenges ahead - Lozano - 2013 - ISBT Science Series - Wiley Online Library
Dr. Carl W. Walter, a Clinical Professor of Surgery at Harvard Medical School, started working at his kitchen in 1947 to produce a plastic bag that could contain and store the blood for transfusions.
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Mycelial fungi completely remediate di(2-ethylhexyl)phthalate, the hazardous plasticizer in PVC blood storage bag
This pioneering work describes how simply, inexpensively and efficiently novel fungi utilize the alarming plasticizer, di(2-ethylhexyl)phthalate (DEHP) blended in PVC blood storage bags (BB). In order to quantify total DEHP (33.5%, w/w) present in BB, it was extracted using n -hexane and confirmed by GC¨CMS.
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Machine learning-assisted non-destructive plasticizer identification and quantification in historical PVC objects based on IR spectroscopy - Nature
8 Citations 17 Altmetric Metrics Abstract Non-destructive spectroscopic analysis combined with machine learning rapidly provides information on the identity and content of plasticizers in PVC...
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Integrated multi-omics investigations reveal the key role of synergistic microbial networks in removing plasticizer di-(2-ethylhexyl) phthalate
Å_±±átW´óWÏû»¯átWÑо¿ÖÐÐÄ Ñо¿³É¹û: ësÕIØ«I ? ÎÄÕ ? ͬÐÐÔu 6 ÒýÎÄ Ë¹¸ßÅÁ˹£¨Scopus£© ¿Ó[ Ö¸¼y ÕªÒª Di- (2-ethylhexyl) phthalate (DEHP) is the most widely used plasticizer worldwide, with an annual global production of more than 8 million tons.
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Integrated multi-omics investigations reveal the key role of synergistic microbial networks in removing plasticizer di-(2-ethylhexyl) phthalate
Di-(2-ethylhexyl) phthalate (DEHP), also 62 named bis(2-ethylhexyl) phthalate), is the most widely used plasticizers worldwide, accounting for 63 approximately one-third and 80% of PAEs produced in the European Union and China, respectively.
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4-Heptanone is a metabolite of the plasticizer di (2-ethylhexyl) phthalate (DEHP) in haemodialysis patients - Oxford Academic
Di(2-ethylhexyl) phthalate (DEHP) is the major plasticizer used in polyvinyl chloride (PVC) products to achieve the desired softness and stability for specific applications. It is incorporated into electrical cables, clothing, wall coverings, flooring and many medical devices, where it may constitute up to 40% by weight.
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Stabilization of lipid membranes through partitioning of the blood bag plasticizer di-2-ethylhexyl phthalate (DEHP). - Semantic Scholar
The presence of DEHP in the bilayers resulted in subtle, yet statistically significant, alterations in several membrane properties in both, the X-ray diffraction experiments and MD simulations, indicating the formation of thicker, stiffer membranes with increased local curvature. The safe storage of blood is of fundamental importance to health care systems all over the world. Currently ...
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